The Science Now Growing Human Brain Cells in Rats

Just in case you didn’t know, all of the restrictions about creating humanoid cyborgs and mixed human-animal crossbreeds have either been removed or did not exist in the first place.

Academia is currently in the process of creating various human-animal crossbreeds, and they will soon have cyborg elements.

Have you guys seen the trailer for this game Scorn?

Basically, in the future, everything is going to look like that.

Unless Kanye West defeats the Jews, that is.

AP:

Scientists have transplanted human brain cells into the brains of baby rats, where the cells grew and formed connections.

It’s part of an effort to better study human brain development and diseases affecting this most complex of organs, which makes us who we are but has long been shrouded in mystery.

“Many disorders such as autism and schizophrenia are likely uniquely human” but “the human brain certainly has not been very accessible,” said said Dr. Sergiu Pasca, senior author of a study describing the work, published Wednesday in the journal Nature.

Approaches that don’t involve taking tissue out of the human brain are “promising avenues in trying to tackle these conditions.”

The research builds upon the team’s previous work creating brain “organoids,” tiny structures resembling human organs that have also been made to represent others such as livers, kidneys, prostates, or key parts of them.

To make the brain organoids, Stanford University scientists transformed human skin cells into stem cells and then coaxed them to become several types of brain cells. Those cells then multiplied to form organoids resembling the cerebral cortex, the human brain’s outermost layer, which plays a key role in things like memory, thinking, learning, reasoning and emotions.

Scientists transplanted those organoids into rat pups 2 to 3 days old, a stage when brain connections are still forming. The organoids grew so that they eventually occupied a third of the hemisphere of the rat’s brain where they were implanted. Neurons from the organoids formed working connections with circuits in the brain.

Bright green: human brain cells.

Human neurons have been transplanted in rodents before, but generally in adult animals, usually mice. Pasca, a psychiatry professor at the Stanford School of Medicine, said this is the first time these organoids have been placed into early rat brains, creating “the most advanced human brain circuitry ever built from human skin cells and a demonstration that implanted human neurons can influence an animal’s behavior.”

To examine a practical use of this approach, scientists transplanted organoids into both sides of a rat’s brain: one generated from a healthy person’s cells and another from the cells of a person with Timothy syndrome, a rare genetic condition associated with heart problems and autism spectrum disorder.

Five to six months later, they saw effects of the disease related to the activity of the neurons. There were differences in the two sides’ electrical activity, and the neurons from the person with Timothy syndrome were much smaller and didn’t sprout as many extensions that pick up input from nearby neurons.

Researchers, whose study was funded partly by the National Institutes of Health, said they could do the same sorts of experiments using organoids made from the cells of people with disorders such as autism or schizophrenia — and potentially learn new things about how these conditions affect the brain, too.

Dr. Flora Vaccarino of Yale University – who previously grew lumps containing cerebral cortex that were made with DNA from people with autism – said the study moves the field forward.

It’s extremely impressive what they do here in terms of what these cells can actually show us in terms of their advanced development … in the rat,” said Vaccarino, who wasn’t involved with the study.

They are going to grow a massive artificial human brain to get around the problems with AI. A massive human brain could have a 1000 IQ and then run all of the robots they are building.

They will also install super brains in animal cross-breed cyborgs.

It’s all happening now.