The Science Using Gene Therapy to Make Men Infertile

Elvis Dunderhoff April 20, 2023

Oh.

I didn’t think this was possible?

It is possible?

Would it be possible for someone to do this without telling you?

Huffington Post:

Scientists think they’ve found a new way to offer contraception to men – and this time, they’re going straight for the sperm.

More than 60 years after the female contraceptive pill was first sold in the UK (yes, you read that correctly), scientists think they’ve made a breakthrough in creating a suitable alternative for men.

A study, published in Nature Communications, honed in on mouse sperm. Scientists were able to identify a gene (called Arrdc5) which, when temporarily switched off, made the males infertile.

Scientists are now looking for a drug molecule that might be able to block the protein Arrdc5 produces for a short period of time in humans.

Dr Jon Oatley from Washington State University is the senior author of the study, and he described it as a “once-in-a-decade discovery”.

Don’t get too excited just yet, though.

Plenty more needs to be done before scientists can fully understand the Arrdc5 protein and its relationship with sperm, but it’s an optimistic start and human trials have already begun.

If it were to be successful, it would mean scientists wouldn’t have to look at interfering with testosterone levels. Previous efforts to use hormonal birth control pills for men have been criticised for triggering mood disorders and shrinking testicles.

However, Professor Richard Anderson of the University of Edinburgh – who was not part of the study – said there was still “a long way to go to make it a male contraceptive” and that it could also be a “potential cause of infertility”.

Haha.

Yeah.

Maybe.

Huh?


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