Disease Resistance to Antibiotics at Tipping Point, Expert Warns

Haroon Siddique
The Guardian
January 10, 2014

antibiotics_pills

The director of the Wellcome Trust has warned that resistance of disease to antibiotics has reached a tipping point at which it could creep into the UK almost without notice.

Prof Jeremy Farrar said the effects would be gradual and would be seen not just in resistant new infections but in everyday medical practice and the treatment of everything from diabetes to minor wounds at risk of turning septic.

Having worked in Vietnam for the past 18 years Farrar said he had already seen firsthand resistance to drugs in the shape of tuberculosis that had spread from patients’ lungs to their brain.

“This is happening now,” Farrar told BBC Radio 4’s Today programme. “It’s been happening for the last decade or so or more and it will continue to happen. What we will see is people actually spending longer in hospital, patients getting sicker and having complications and dying and it will creep up on us almost without us noticing.

“This will not be the sort of contagion-like event of somebody landing from Hong Kong in London with a pneumonia that is emerging that we’ve all feared. This will creep up on us insidiously, and of course that’s in many ways more difficult to cope with.”

He said there had been a “golden age” of antibiotics but complacency had set in in the 1970s and 1980s when there could have been more investment and antibiotics could have been used better, for example in combinations, to prevent the development of resistance to them.

“We’re watching evolution happening,” he said. “The viruses, the parasites have a pressure put on them from the drugs. They want to respond to that by surviving and not being killed by these antibiotics so therefore they evolve in ways that make them resistant.”

Farrar said that 20 years ago there had been 18 companies in the commercial sector working in the field of antibiotics but now there were just four, and consequently only five new classes of antibiotics had emerged in the past 10 years.

Read More