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WHO – Preparing for a bird flu pandemic in humans, including engaging with vaccine manufacturers.
Once in a lifetime has become a constant state of control.
You were warned!
— Bernie’s Tweets (@BernieSpofforth) March 19, 2023
This is very exciting technology.
We’re going to completely eradicate disease by eradicating humans.
Some of the world’s leading makers of flu vaccines say they could make hundreds of millions of bird flu shots for humans within months if a new strain of avian influenza ever jumps across the species divide.
One current outbreak of avian flu known as H5N1 clade 2.3.4.4b has killed record numbers of birds and infected mammals. Human cases, however, remain very rare, and global health officials have said the risk of transmission between humans is still low.
Executives at three vaccine manufacturers – GSK Plc (GSK.L) Moderna Inc (MRNA.O) and CSL Seqirus, owned by CSL Ltd (CSL.AX) – told Reuters they are already developing or about to test sample human vaccines that better match the circulating subtype, as a precautionary measure against a future pandemic.
Others, like Sanofi (SASY.PA), said they “stand ready” to begin production if needed, with existing H5N1 vaccine strains in stock.
There has also been a push among companies to develop a bird flu vaccine for poultry, a market potentially far larger than that for humans.
Less reassuring, however, is that most of the potential human doses are earmarked for wealthy countries in long-standing preparedness contracts, global health experts and the companies said.
Many countries’ pandemic plans say flu shots should go first to the most vulnerable while supply is limited. But during COVID-19, many vaccine-rich countries inoculated large proportions of their populations before considering sharing doses.
“We could potentially have a much worse problem with vaccine hoarding and vaccine nationalism in a flu outbreak than we saw with COVID,” said Dr Richard Hatchett, chief executive of the Coalition for Epidemic Preparedness Innovations (CEPI), which helps fund vaccine research.
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WHO did not comment on the potential for vaccine hoarding in a flu pandemic but said mechanisms were being developed “so that countries can work together – not in competition with each other” to respond to such a crisis. It said it was “fully confident” manufacturers and member states would meet their obligations.
In a pandemic, vaccine manufacturers would shift production of seasonal flu vaccines and instead make shots tailored to the new outbreak when needed. They already have the capacity to make hundreds of millions of doses.
Many of the potential pandemic shots are pre-approved by regulators, based on data from human trials showing the vaccines are safe and prompt an immune response, a process already used with seasonal flu vaccines. This means they might not require further human trials, even if they have to be tweaked to better match whichever strain does jump to humans. Data on how well the vaccines actually protect against infection would be gathered in real-time.
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Experts have long advocated for new approaches in developing vaccines, both for seasonal and pandemic flu. COVID proved the potential of mRNA technology to adapt more quickly to changing viruses because the vaccines use genetic information from the pathogen, rather than having to grow the virus itself.
Moderna’s mRNA vaccine research actually began with pandemic flu, and was modified for COVID, said Raffael Nachbagauer, executive director of infectious diseases at Moderna.
The company plans to launch a small human trial of an mRNA pandemic flu vaccine tailored to the new avian influenza subtype in the first half of 2023, he said, adding Moderna could respond “very quickly” in an outbreak scenario. The results will be closely watched, as the data on Moderna’s seasonal flu candidate was mixed.
It’s psycho, but there is a group of people who will just keep taking these vaccines until they die.
They’re sort of like gamers who buy loot boxes.
